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KMID : 1161520090130020127
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Animal Cells and Systems
2009 Volume.13 No. 2 p.127 ~ p.132
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Overweight of Korean male workers and genetic polymorphism of insulin receptor substrate 1 (IRS1) gene
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Kim Ki-Woong
Heo Kyung-Hwa
Won Yong-Lim
Ko Kyung-Sun
Kim Tae-Gyun
Lee Mi-Young
Park Jung-Sun
Paik Sang-Gi
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Abstract
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We have examined the hypothesis that the Gly972Arg variant of the insulin receptor substrate 1 (IRS1) gene is associated with the components contributing to overweight (obesity) and metabolic syndrome. We describe IRS1 genotype frequencies in 274 Korean men. The frequencies of Gly972Gly (G/G) and Gly972Arg (G/A variant) of the IRS1 gene were 88.3% and 11.7%, respectively, and the differences in frequencies between the overweight (BMI≥25 kg/m2) group and non?overweight (BMI<25 kg/m2) group were statistically significant. The subjects with G/A variant of IRS1 gene in non?overweight had significantly higher level of visceral fat thickness and adiponectin/leptin ratio than those with G/G alleles. In overweight group, the subjects with G/A variant of IRS1 gene also showed significantly higher level of insulin than those with G/G alleles. These results suggest that the IRS1 genetic polymorphism is involved in the occurrence of overweight, as well as metabolic syndrome.
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KEYWORD
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obese (overweight), IRS1 genetic polymorphism, Korean men
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